L-Met Activates Arabidopsis GLR Ca2+ Channels Upstream of ROS and Regulates Stomatal Movement.
Dongdong Kong, Heng-Chen Hu, Eiji Okuma, Yuree Lee, Hui Sun Lee, Shintaro Munemasa, Daeshik Cho, Leah Pedoeim, Barbara Rodriguez, Wonpil Im, Yoshiyuki Murara, Zhen-Ming Pei, June M. Kwak.
(submitted).
G-LoSA: An Efficient Computational Tool for Local Structure-Centric Biological Studies and Drug Design.
Hui Sun Lee and Wonpil Im.
Protein Sci. 2016, 25: 865-876.
Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions.
Ji Hoon Lee, Misook Oh, H.S. Kim, Hui Sun Lee, Wonpil Im, and Hyun-Suk Lim.
ACS Comb. Sci. 2016, 18: 36-42.
GS-align for Glycan Structure Alignment and Similarity Measurement.
Hui Sun Lee, Sunhwan Jo, Srayanta Mukherjee, Sang-Jun Park, Jeffrey Skolnick, Jooyoung Lee, and Wonpil Im.
Bioinformatics 2015, 31: 2653-2659.
Potential Application of Alchemical Free Energy Simulations to Discriminate GPCR Ligand Efficacy.
Hui Sun Lee, Chaok Seok, and Wonpil Im.
J. Chem. Theory Comput. 2015, 11: 1255-1266.
Effects of N-glycosylation on Protein Conformation and Dynamics: Protein Data Bank Analysis and Molecular Dynamics Simulation Study.
Hui Sun Lee, Yifei Qi, and Wonpil Im.
Sci. Rep. 2015, 5: 8926.
Design, Solid-Phase Synthesis, and Evaluation of a Phenyl-Piperazine-Triazine Scaffold as α-Helix Mimetics.
Woo Sirl Lee, Hee-Jo Moon, Misook Oh, Hui Sun Lee, Ji Hoon Lee, Wonpil Im, and Hyun-Suk Lim.
ACS Comb. Sci. 2014, 16: 695-701.
Lipid-Linked Oligosaccharides in Membranes Sample Conformations that Facilitate Binding to Oligosaccharyltransferase.
Nathan R. Kern, Hui Sun Lee, Emilia L. Wu, Soohyung Park, Kenno Vanommeslaeghe, Alexander D. MacKerell, Jr., Jeffery B. Klauda, Sunhwan Jo, and Wonpil Im.
Biophys. J. 2014, 107:1885-1895.
CHARMM-GUI PDB Manipulator for Advanced Modeling and Simulations of Proteins Containing Non-standard Residues.
Sunhwan Jo, Xi Cheng, Shahidul M. Islam, Lei Huang, Huan Rui, Allen Zhu, Hui Sun Lee, Yifei Qi, Wei Han, Kenno Vanommeslaeghe, Alexander D. MacKerell, Jr., Benoît Roux, and Wonpil Im.
Adv. Protein Chem. Struct. Biol. 2014, 96: 235-265.
Potential Pharmacological Chaperones Targeting Cancer-associated MCL-1 and Parkinson’s Disease-associated α-synuclein.
Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Woo Sirl Lee, Christopher Burlak, Wonpil Im, Quyen Hoang, and Hyun-Suk Lim.
Proc. Natl. Acad. Sci. U. S. A. 2014, 111: 11007-11012.
Ligand binding site detection by local structure alignment and its performance complementarity.
Hui Sun Lee and Wonpil Im.
J. Chem. Inf. Model. 2013, 53: 2462-2470.
CHARMM-GUI micelle builder for pure/mixed micelle and protein/micelle complex systems.
Xi Cheng, Sunhwan Jo, Hui Sun Lee, Jeffery B. Klauda and Wonpil Im.
J. Chem. Inf. Model. 2013, 53: 2171-2180.
Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling.
Sunhwan Jo, Hui Sun Lee, Jeffrey Skolnick and Wonpil Im.
PLoS Comput. Biol. 2013, 9: e1002946.
CHARMM-GUI ligand binder for absolute binding free energy calculations and its application.
Sunhwan Jo, Wei Jiang, Hui Sun Lee, Benoît Roux, and Wonpil Im.
J. Chem. Inf. Model. 2013, 53: 267-277.
Potentiation of anti-angiogenic activity of heparin by blocking the ATIII interacting pentasaccharide unit and increasing net anionic charge.
Seung Woo Chung, Myungjin Lee, Sang Mun Bae, Jooho Park, Ok Cheol Jeon, Hui Sun Lee, Han Choe, Han Sung Kim, Beom Suk Lee, Rang-Woon Park, Sang Yoon Kim, Youngro Byun.
Biomaterials 2012, 33: 9070-9079.
Identification of ligand templates using local structure alignment for structure-based drug design.
Hui Sun Lee and Wonpil Im.
J. Chem. Inf. Model. 2012, 52: 2784-2795.
Application of absolute binding free energy calculations to prediction of binding modes and affinities of MDM2 and MDMX inhibitors.
Hui Sun Lee, Sunhwan Jo, Hyun-Suk Lim, and Wonpil Im.
J. Chem. Inf. Model. 2012, 52: 1821-1832.
zVLL-CHO at low concentrations acts as a calpain inhibitor to protect neurons against okadaic acid-induced neurodegeneration.
Seung-Yong Yoon, Jung-Eun Choi, Ju-Hee Ham, Han Choe, Hui Sun Lee, and Dong-Hou Kim.
Neurosci. Lett. 2012, 10: 33-38.
BSP-SLIM: a blind low-resolution ligand-protein docking approach using theoretically predicted protein structures.
Hui Sun Lee and Yang Zhang.
Proteins 2012, 80: 93-110.
Structural basis of cooperativity in human UDP-glucose dehydrogenase.
Venkatachalam Rajakannan, Hui Sun Lee, Seon-Ha Chong, Han-Bong Ryu, Ji-Young Bae, Eun-Young Whang, Jae-Wan Huh, Sung-Woo Cho, Lin-Woo Kang, Han Choe, and Robert C. Robinson.
PLoS One 2011 6: e25226.
Status of GPCR modeling and docking as reflected by community wide GPCR Dock 2010 assessment.
Irina Kufareva, Manuel Rueda, Vsevolod Katritch, GPCR Dock 2010 participants (Hui Sun Lee), Raymond C. Stevens, and Ruben Abagyan.
Structure 2011, 19: 1108–1126.
1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists.
Jiwon Choi, Yunsun Park, Hui Sun Lee, Young Yang, and Sukjoon Yoon.
Bioorg. Med. Chem. 2010, 18:8315-8323.
Expression, high cell density culture and purification of recombinant EC-SOD in Escherichia coli.
Young-Jin Son, Ji-Young Bae, Seon-Ha Chong, Hui Sun Lee, Sang Hyun Mo, Tae Yoon Kim, and Han Choe.
Appl. Biochem. Biotechnol. 2010, 162:1585-1598.
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
Yong-Whan Lim, Seung-Yong Yoon, Jung-Eun Choi, Sang-Min Kim, Hui Sun Lee, Han Choe, Seung-Chul Lee and Dong-Hou Kim.
Biochem. Biophys. Res. Commun. 2010, 395:207-212.
Identification of (β-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor γ activity.
Jiwon Choi, Yoonae Ko, Hui Sun Lee, Yun Sun Park, Young Yang and Sukjoon Yoon.
Eur. J. Med. Chem. 2010, 45: 193-202.
Improving virtual screening performance against conformational variations of receptors by shape matching with ligand binding pocket.
Hui Sun Lee, Cheol Soon Lee, Jeong Sook Kim, Dong Hou Kim, Han Choe.
J. Chem. Inf. Model. 2009, 49: 2419-2428.
Transposon-directed base-exchange mutagenesis (TDEM): A novel method for multiple-nucleotides substitution within a target gene.
Yun Cheoul Kim, Hui Sun Lee, Sukjoon Yoon and Sherie L. Morrison.
Biotechniques 2009, 46: 534-542.
H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.
Su-Hyung Jo, Hee-Kyung Hong, Seon Ha Chong, Hui Sun Lee, Han Choe.
Pharmacol. Res. 2009, 60: 429-437.
A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated alpha7 nicotinic acetylcholine receptor regulation.
Byung-Hwan Lee, Sun-Hye Choi, Mi Kyung Pyo, Tae-Joon Shin, Sung-Hee Hwang, Bo-Ra Kim, Sang-MoK Lee, Jun-Ho Lee, Joon-Hee Lee, Hui Sun Lee, Han Choe, Kyou-Hoon Han, Hyoung-Chun Kim, Hyewhon Rhim, Joon-Hwan Yong and Seung-Yeol Nah.
Mol. Cells 2009, 27: 591-599.
A novel program to design siRNAs simultaneously effective to highly variable virus genomes.
Hui Sun Lee, Jeonghyun Ahn, Eun Jung Jun, Sanghwa Yang, Chul Hyun Joo, Yoo Kyum Kim, Heuiran Lee.
Biochem. Biophys. Res. Commun. 2009, 384: 431-435.
Computational analysis of the quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase.
Hui Sun Lee, Young Jin Son, Seon Ha Chong, Ji Young Bae, Chae Hun Leem, Yeon Jin Jang, Han Choe.
Arch. Biochem. Biophys. 2009, 486: 35-43.
Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.
Young Jin Kim, Hee Kyung Hong, Hui Sun Lee, Sang Hyun Moh, Jong Cook Park, Su Hyun Jo and Han Choe.
J. Cardiovasc. Pharmacol. 2008, 52: 485-493.
Optimization of high throughput virtual screening by combining shape-matching and docking methods.
Hui Sun Lee, Jiwon Choi, Irina Kufareva, Ruben Abagyan, Anton Filikov, Young Yang, Sukjoon Yoon.
J. Chem. Inf. Model. 2008, 48: 489-497.
Evaluation of advanced structure-based virtual screening methods for computer-aided drug discovery.
Hui Sun Lee, Jiwon Choi, Sukjoon Yoon.
Genomics & Informatics 2007 Mar 5(1): 24-29.
QHELIX: a computational tool for the improved measurement of inter-helical angles in proteins.
Hui Sun Lee, Jiwon Choi, Sukjoon Yoon.
Protein J. 2007 26: 556-561.
Universal and mutation-resistant anti-enteroviral activity: potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region.
Hui Sun Lee, Jeonghyun Ahn, Youngmee Jee, Il Sun Seo, Eun Jung Jeon, Eun-Seok Jeon, Chul Hyun Joo, Yoo Kyum Kim, Heuiran Lee.
J. Gen. Virol. 2007 88: 2003-2012.
Contributions of 3´-overhang to the dissociation of small interfering RNAs from the PAZ domain: molecular dynamics simulation study.
Hui Sun Lee, Soo Nam Lee, Chul Hyun Joo, Heuiran Lee, Han Saem Lee, Seung Yong Yoon, Yoo Kyum Kim, Han Choe.
J. Mol. Graph. Model. 2007 25:784-793.
Targeted molecular dynamics simulation studies of calcium binding and conformational change in the C-terminal half of gelsolin.
Hui Sun Lee, Robert Charles Robinson, Chul Hyun Joo, Heuiran Lee, Yoo Kyum Kim, Han Choe.
Biochem. Biophys. Res. Commun. 2006 342:702-709.
A novel hypothesis for the binding mode of HERG channel blockers.
Han Choe, Kwang Hoon Nah, Soo Nam Lee, Han Sam Lee, Hui Sun Lee, Su Hyun Jo, Chae Hun Leem, Yeon Jin Jang.
Biochem. Biophys. Res. Commun. 2006 344:72-78.
Quantitative analysis of viral RNA in the murine heart and pancreas with different concentration of coxsackievirus B3.
Eun Ok Kim, Chul Hyun Joo, Jeong Sook Ye, Eun Jung Jun, Hui Sun Lee, Won-Ki Min, Moo-Song Lee, Heuiran Lee, Yoo Kyum Kim.
Intervirology 2006 49:192-199.
A small interfering RNA targeting coxsackievirus B3 protects permissive Hela cells from viral challenge.
Jeonghyun Ahn, Eun Seok Jun, Hui Sun Lee, Seung Yong Yoon, DongHou Kim, Chul-Hyun Joo, Yoo Kyum Kim, Heuiran Lee.
J. Virol. 2005 79: 8620-8624.
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures.
Seung Yong Yoon, Jung Eun Choi, Jae-Wan Huh, Onyou Hwang, Hui Sun Lee, Hea Nam Hong, Donghou Kim.
Cell Motil. Cytoskeleton 2005 60: 181-190.
Distribution of viral RNA in mouse tissues during acute phase of coxsackievirus B5 infection.
Mi Sun Moon, Chul Hyun Joo, In Seok Hwang, Jeong Sook Ye, Eun Jung Jun, Hui Sun Lee, Donghou Kim, Min-Jae Lee, Heuiran Lee, Yoo Kyum Kim.
Intervirology 2005 48: 153-160.
Morphologies of binary AB/AC diblock copolymer blends.
Seung Hyun Kim, Hui Sun Lee, Moo Sung Lee, Won Ho Jo.
Macromol. Chem. Phys. 2002 203: 2188-2195.
The effect of a transesterification catalyst on the morphology of PC/PMMA blends.
Moo Sung Lee, Min Kyu Ha, Hui Sun Lee, Won Ho Jo.
J. Korean Fiber Soc. 2001 38: 51-57.