Workshop to Take Aim at Bacteria
November 18 (Friday), 2016 | Lehigh University, Bethlehem, PA
About the workshop
This workshop is to bring people from academia, industry, and governmental and non-governmental organizations to talk about their research and efforts toward developing antibiotics and vaccines with multidisciplinary technical advances.
Funding for the workshop is provided by:
- Office of Research and Graduate Studies -
- Department of Biological Sciences -
Speakers
- Angela Brown (Lehigh University)
Inhibition of Cholesterol Binding As an Anti-Virulence Strategy
- Anna Konovalova [in Tom Silhavy’s lab, Princeton University]
Rcs Envelope Stress Response Detects and Counteracts Cationic Antimicrobial Peptides
- Bryan Berger (Lehigh University)
Design and Selection of Broad-spectrum, Polysaccharide Degrading Enzymes for Polymicrobial Biofilm Removal
- Carolyn Shore (Pew Charitable Trusts)
- Charlie Brooks (University of Michigan)
In Silico High-throughput Chemical Space Exploration for Inhibitor Refinement Using Multi-Site Lambda Dynamics
- Francesca M. Marassi (Sanford Burnham Prebys Medical Discovery Institute)
Membrane Protein Mediators of Pathogen-host Interactions
- Karen Fleming (Johns Hopkins University)
Driving Forces for Sorting and Folding of Outer Membrane Beta Barrels
- Linda Columbus (The University of Virginia)
Bacterial-host interactions: Can Our Approach and Understanding Impact Resistance?
- Margaret C. Bash (Food and Drug Administration)
Outer Membrane Protein Antigenic Diversity and Vaccine Development for the Pathogenic Neisseria
- Marcos Pires (Lehigh University)
Bacterial Immunotherapies Based on Surface Remodeling
- Mathias Winterhalter (Jacob University)
Permeation Across the Outer Cell Wall
- Phillip E. Klebba (Kansas State University)
High-throughput Screening for Inhibitors of TonB-dependent Iron Transport by Gram-negative Bacteria
- Richard W. Pastor (National Institutes of Health)
MD Simulations AMP Piscidin 1 Indicate Instability of Small Pores
- Robert Stavenger (GlaxoSmithKline plc)
IMI TRANSLOCATION and ENABLE: Collaborative Drug Discovery in Action
- Ruben Tommasi (Entasis Inc)
Improving Our Understanding of Porin Permeability in Gram-negative Bacteria
- Wonpil Im (Lehigh University)
Modeling and Simulation of Bacterial Outer Membranes and Interactions with Proteins
Program
| 08:00 - 08:20 | Registration / Breakfast |
| 08:20 - 09:45 | Wonpil Im (Chair) |
| o Alan Snyder | Opening Remarks (Vice President and Associate Provost for Research and Graduate Studies) |
| o Robert Stavenger | IMI TRANSLOCATION and ENABLE: Collaborative Drug Discovery in Action |
| o Mathias Winterhalter | Permeation Across the Outer Cell Wall |
| o Ruben Tommasi | Improving Our Understanding of Porin Permeability in Gram-negative Bacteria |
| 09:45 - 10:15 | Break |
| 10:15 - 11:55 | Bryan Berger (Chair) |
| o Margaret C. Bash | Outer Membrane Protein Antigenic Diversity and Vaccine Development for the Pathogenic Neisseria |
| o Marcos Pires | Bacterial Immunotherapies Based on Surface Remodeling |
| o Francesca M. Marassi | Membrane Protein Mediators of Pathogen-host Interactions |
| o Richard W. Pastor | MD Simulations AMP Piscidin 1 Indicate Instability of Small Pores |
| 11:55 - 13:20 | Lunch |
| 13:20 - 15:00 | Marcos Pires (Chair) |
| o Angela Brown | Inhibition of Cholesterol Binding As an Anti-Virulence Strategy |
| o Anna Konovalova | Rcs Envelope Stress Response Detects and Counteracts Cationic Antimicrobial Peptides |
| o Phillip E. Klebba | High-throughput Screening for Inhibitors of TonB-dependent Iron Transport by Gram-negative Bacteria |
| o Charlie Brooks | In Silico High-throughput Chemical Space Exploration for Inhibitor Refinement Using Multi-Site Lambda Dynamics |
| 15:00 - 16:00 | Break |
| 16:00 - 17:40 | Angela Brown (Chair) |
| o Bryan Berger | Design and Selection of Broad-spectrum, Polysaccharide Degrading Enzymes for Polymicrobial Biofilm Removal |
| o Karen Fleming | Driving Forces for Sorting and Folding of Outer Membrane Beta Barrels |
| o Linda Columbus | Bacterial-host interactions: Can Our Approach and Understanding Impact Resistance? |
| o Wonpil Im | Modeling and Simulation of Bacterial Outer Membranes and Interactions with Proteins |
| 18:30 - | Dinner |
Registration
Registration deadline
November 1, 2016
Location
Governor's Suite
Iacocca Hall
111 Research Drive
Bethlehem, PA 18015
GPS: 40.601490,-75.359985